Lab Tested Purity
Verified >99% pure via HPLC.
Lyophilized Powder
Ensures maximum stability.
Express Shipping
Discreetly shipped from Canada.
Research Only
Not for human consumption.
VIP 5mg
$63.00
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide with documented effects across immune modulation, neuroprotection, vasodilation, gastrointestinal motility, and circadian regulation. Research uses VIP to study TNF-α suppression, regulatory T-cell induction, and neurovascular signaling. 99%+ HPLC purity, in-vitro only.
8 in stock
VIP 5mg — Vasoactive Intestinal Peptide for Anti-Inflammatory and Neuroimmune Research
Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide originally isolated from porcine intestine, where it was identified for its vasodilatory and intestinal motility-regulating effects. Since its discovery, VIP has been recognized as one of the most pleiotropic signaling peptides in mammalian physiology, with documented roles in immune modulation, neuroprotection, circadian regulation, and pulmonary function. The 5mg vial offers researchers practical quantities for studying these diverse pathways within the immune support peptides research category.
Anti-Inflammatory and Immunoregulatory Action
VIP exerts strong anti-inflammatory effects through binding to VPAC1 and VPAC2 G-protein-coupled receptors expressed broadly on immune cells. Research has demonstrated that VIP suppresses production of pro-inflammatory cytokines including TNF-α, IL-6, IL-12, and IFN-γ, while concurrently promoting anti-inflammatory mediators such as IL-10 and TGF-β. VIP has also been shown to shift T-cell polarization toward regulatory T-cell phenotypes, reinforcing immune tolerance in laboratory models of autoimmunity.
Neuroprotection and Cognitive Research
Beyond its immune role, VIP has been studied for neuroprotective effects in models of neurodegeneration, stroke, and traumatic brain injury. Research has documented preservation of neuronal viability, reduction of glial activation, and improved synaptic function following VIP exposure in cultured neurons and animal models. Investigators have also explored VIP’s effects on memory and cognitive processes through its modulation of hippocampal signaling and BDNF expression in research animals.
Pulmonary and Vascular Research
VIP’s classical role as a vasodilator continues to be relevant in modern research, with studies examining its effects on pulmonary arterial relaxation, bronchodilation, and vascular endothelial function. Animal models of pulmonary arterial hypertension and chronic obstructive lung pathology have shown VIP-induced improvements in measured hemodynamic parameters and airway resistance, supporting its use as a reference compound in cardiopulmonary investigations.
Circadian and Mast-Cell Studies
VIP is a key signaling molecule in the suprachiasmatic nucleus of the hypothalamus, the master circadian pacemaker, and research has used VIP to probe circadian rhythm regulation in cell culture and rodent studies. Separately, VIP modulates mast-cell activation and degranulation, offering researchers a tool for investigating histamine-driven inflammatory cascades and allergic-response pathways in controlled laboratory settings.
Gastrointestinal Motility and Mucosal Research
True to its name, VIP retains active roles in gastrointestinal physiology including smooth muscle relaxation, secretory regulation, and mucosal blood flow. Research has examined VIP’s effects in models of inflammatory bowel disease, irritable bowel pathology, and post-surgical ileus, where its combined anti-inflammatory and motility-regulating profile generates a multi-mechanism research read-out.
Comparison With Related Immune Peptides
VIP is frequently studied in parallel with other immune-modulating peptides such as KPV and Thymosin Alpha-1, allowing researchers to compare vasoactive-neuropeptide signalling against melanocortin and thymic pathways. These parallel studies help characterise where VIP sits in the broader landscape of immune-support peptide research.
Quality, Storage, and Compliance
Each vial of VIP 5mg is manufactured to 99%+ HPLC-verified purity and supplied as a sterile lyophilized powder. Store unreconstituted vials at -20°C; reconstituted material should be refrigerated at 2–8°C and protected from light. This VIP product is sold strictly for in-vitro laboratory research only — not for human consumption, diagnostic use, or any clinical application. Buyers must comply with all applicable provincial and federal regulations.
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