Mots-C 10mg

MOTS-c 10mg — Mitochondrial-Derived Peptide for Metabolic and Aging Research

MOTS-c (Mitochondrial Open Reading frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded by the mitochondrial genome rather than the nuclear genome, making it part of a distinct class of mitochondrial-derived peptides (MDPs). Discovered relatively recently, MOTS-c has rapidly become one of the most studied mitochondrial peptides in metabolic and aging research, generating dozens of peer-reviewed publications and establishing itself in the anti-aging peptides research category.

Mitochondrial Origin and Significance

The discovery that mitochondrial DNA encodes biologically active peptides like MOTS-c challenged the prevailing dogma that mitochondrial DNA encoded only proteins involved in oxidative phosphorylation. MOTS-c represents a new paradigm in which mitochondria communicate with the rest of the cell through specifically encoded peptide signals, opening entire new fields of research into mitochondrial-nuclear communication.

Metabolic Regulation

MOTS-c functions as a metabolic regulator with effects spanning glucose homeostasis, insulin sensitivity, and energy metabolism. Research has documented that MOTS-c activates AMPK signaling, promotes glucose uptake in skeletal muscle, and improves insulin sensitivity in animal models of metabolic dysfunction. These effects have positioned MOTS-c as a key research compound in studies of metabolic disease and energy metabolism.

Exercise Physiology Research

MOTS-c levels increase with exercise, and the peptide appears to mediate some of the beneficial metabolic adaptations to physical activity. Research has examined MOTS-c’s role in exercise-induced improvements in metabolism, including effects on substrate utilization, mitochondrial function, and adaptation to training stimuli in animal models.

Aging and Longevity Research

Given mitochondrial dysfunction’s central role in aging, MOTS-c has attracted substantial interest in longevity research. Studies have documented that MOTS-c levels decline with age, and exogenous MOTS-c administration improves multiple aging biomarkers in research animals. These findings have positioned MOTS-c as an important tool for investigating mitochondrial contributions to aging biology in laboratory settings.

Obesity and Adiposity Research

Research has documented MOTS-c effects on body composition, particularly adipose tissue, in animal models. Studies have shown that MOTS-c reduces diet-induced obesity, improves adipose tissue metabolic function, and modulates inflammatory parameters associated with adipose dysfunction, generating broad relevance across metabolic research programs.

Comparison With Related Anti-Aging Peptides

MOTS-c is frequently studied alongside other mitochondrial and longevity peptides such as Humanin, Epithalon, and small-molecule ERRα agonists like SLU-PP-332. Parallel investigations clarify how mitochondrial-derived peptide signaling compares with nuclear-receptor activation in matched research designs.

Quality, Storage, and Compliance

Each vial of MOTS-c 10mg is manufactured to 99%+ HPLC-verified purity and supplied as a sterile lyophilized powder. Store unreconstituted vials at -20°C; reconstituted material should be refrigerated at 2–8°C. This MOTS-c product is sold strictly for in-vitro laboratory research only — not for human consumption, diagnostic use, or any clinical application. Buyers must comply with all applicable provincial and federal regulations.